Nucleoside Transporters

Nucleoside transporters (NTs) are a class of transmembrane proteins responsible for mediating the transmembrane transport of nucleosides and nucleoside analogs. They are widely expressed in mammalian cells and are classified into two major families based on their transport mechanisms and substrate specificities: equilibrative nucleoside transporters (ENTs/SLC29) and concentrative nucleoside transporters (CNTs/SLC28). ENTs have four subtypes (hENT1-4), which passively transport nucleosides through concentration gradients. CNTs have three subtypes (hCNT1-3), which actively uptake nucleosides dependent on sodium ion gradients.
Nucleoside transporters can be used in research on cardiovascular diseases, cancer, and viral diseases^[1]^[2]^[3].

References:

[1]. Playa H, et al. Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2). Bioorg Med Chem Lett. 2014 Dec 15;24(24):5801-5804. [Content Brief]

[2]. Yamamoto T, et al. Ribavirin uptake by cultured human choriocarcinoma (BeWo) cells and Xenopus laevis oocytes expressing recombinant plasma membrane human nucleoside transporters[J]. European journal of pharmacology, 2007, 557(1): 1-8. [Content Brief]

[3]. Choudhuri S, et al. The biology of nutrients: genetic and molecular principles[M]//Nutraceuticals. Academic Press, 2016: 209-225.

Nucleoside Transporters Inhibitors (6)

Nucleoside Transporters Related Products (6):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-100957

Dilazep dihydrochloride	Inhibitor	99.64%
Dilazep dihydrochloride is an inhibitor of adenosine uptake. Dilazep dihydrochloride has cerebral and coronary vasodilating action through enhancement of effect of adenosine. Dilazep dihydrochloride also inhibits the ischemic damage, platelet aggregation, and membrane transport of nucleosides.

HY-110165

hENT4-IN-1	Inhibitor	99.94%
hENT4-IN-1 is a potent and selective human ENT4 (equilibrative nucleoside transporter 4) inhibitor with an IC₅₀ of 74.4 nM.

HY-112843

CNT2 inhibitor-1	Inhibitor	98.77%
CNT2 inhibitor-1 is a potent concentrative nucleoside transporter 2 Inhibitor (CNT2), with an IC₅₀ of 640 nM for hCNT2.

HY-116927

KW-7158	Inhibitor
KW-7158 is a putative afferent nerve inhibitor that can depress vesica-vascular reflexes in rats. KW-7158 is an inhibitor of nucleoside transporter-1 (ENT1/SLC29A1) and acts as an antagonist for overactive bladder (OAB).

HY-115366

Soluflazine	Inhibitor	98.86%
Soluflazine is a nucleoside transport inhibitor with anticonvulsant action. Soluflazine can be used as an antiepileptic agent.

HY-124795

FPMINT	Inhibitor
FPMINT is a potent, irreversible and non-competitive inhibitor of Equilibrative nucleoside transporters (ENTs), which is more selective to ENT2 than to ENT1. FPMINT plays an important role in uridine uptake.

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